HOME » 所属検索 » 研究者名リスト (医学部・医学系研究科・附属病院) » 大石 晃嗣 詳細
ヒト造血幹細胞から様々なリンパ球への分化を支持する培養系を世界に先駆けて開発し、その培養系を用いて、ヒトリンパ球分化のメカニズムを解明しています。移植療法や遺伝子治療への応用をめざししています。
●細胞移植 ●遺伝子治療
●FACSCantll ●Luminex
●オーソオートビュー
など
●Nakamori Y, Liu B, Ohishi K, et al: Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis. Br J Haematol. 157(6):674-86, 2012.
●Suzuki K, Ono R,Ohishi K, et al: IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells. Suzuki K, Ono R, Ohishi K, . Int J Oncol. 40 (1):53-62, 2012
●Yamamura K, Ohishi K, Masuya M, et al: Ex Vivo Culture of Human Cord Blood Hematopoietic Stem/Progenitor Cells Adversely Influences Their Distribution to Other Bone Marrow Compartments after Intra-bone Marrow Transplantation. Stem cells. 26:543-9, 2008.
●Yamamura K, Ohishi k, Katayama N, et al: Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptor a-positive and -negative human hematopoietic progenitors. Cancer Sci. 98:1597-603, 2007.
●Yamamura K, Ohishi (equally contribution), Katayama N, et al: Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis. Br J Haematol 135: 242-53, 2006.
●Ohishi K, Barnum-Finney B, Bernstein I.D. The Notch pathway: modulation of cell fate decisions in hematopoiesis. International Journal of Hematology. 75:449-59, 2002. Review
●Ohishi K, Varnum-Finney B, Bernstein I.D. Delta-1 enhances marrow and thymic repopulating ability of human CD34+CD38- cord blood cells. Journal of Clinical Investigation. 110:1165–74, 2002.
●Ohishi K, Varnum-Finney B, Serda R.E, et al. The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells. Blood. 98:1402-07, 2001.
●日本内科学会(総合内科専門医) ●日本癌学会
●日本エイズ学会 ●日本血液学会(血液専門医・指導医、代議員)
●日本感染症学会 ●日本臨床腫瘍学会(暫定指導医)
●日本輸血・細胞治療学会(認定医) ●米国血液学会
●日本造血細胞移植学会