2012年更新

主な保有技術

●二光子レーザー顕微鏡
●分子生物学的アプローチ(血清、組織における遺伝子発現、メチレーション、マイクロRNA発現、タンパク発現)

受賞

●2010年　FRANK ELLIS MEDAL Award
●2009年　大腸癌研究会:優秀演題賞
●2009年　日本癌治療学会:優秀演題賞
●2007年　三重大学:Young Investigation Awards

著書

●Toiyama Y et al. The Diagnostic, Prognostic, and Predictive Potential of MicroRNA Biomarkers in Colorectal Cancer. Current Colorectal Cancer Reports (12 January 2012), pp. 1-10.
●Hur K, Toiyama Y, Takahashi M　et al. MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis.Gut. 2012 Jul 10.
●Garcia M, Choi C, Kim HR, Daoud Y, Toiyama Y et al. Association Between Recurrent Metastasis From Stage II and III Primary Colorectal Tumors and Moderate Microsatellite Instability. Gastroenterology. 2012 Jul;143(1):48-50.e1.
●Toiyama Y et al. Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer. Int J Oncol. 2012 Feb;40(2):560-6.
●Toiyama Y et al. Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case. Surg Today. 2011 Oct;41(10):1442-6.
●Toiyama Y et al. Co-expression of hepatocyte growth factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte growth factor/c-Met signaling in gastric cancer. Int J Cancer. 2012 Jun 15;130(12):2912-21.
●Toiyama Y et al. DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness. J Gastroenterol. 02/2011; 46(2):153-63.
●Toiyama Y et,al. Gene Expression Profiles of Epidermal Growth Factor Receptor, Vascular Endothelial Growth Factor and Hypoxia-inducible Factor-1 with Special Reference to Local Responsiveness to Neoadjuvant Chemoradiotherapy and Disease Recurrence After Rectal Cancer Surgery. Clin Oncol (R Coll Radiol). 2010 Jan 29.
●Toiyama Y et,al.Loss of tissue expression of interleukin-10 promotes the disease progression of colorectal carcinoma. Surg Today. 01/2010; 40(1):46-53.
●Toiyama Y et,al. Intravital imaging of DSS-induced cecal mucosal damage in GFP-transgenic mice using two-photon microscopy. J Gastroenterol. 2010 Jan 9
●Toiyama Y et,al. Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients. Int J Cancer. 2009 Oct 1;125(7):1657-62.
●Toiyama Y et,al. Circulating form of human vascular adhesion protein-1 (VAP-1): decreased serum levels in progression of colorectal cancer and predictive marker of lymphatic and hepatic metastasis. J Surg Oncol. 2009 May 1;99(6):368-72.
●Toiyama Y et,al. Overexpression of the signal peptide whirlin isoform 2 is related to disease progression in colorectal cancer patients. Int J Oncol. 2009 Oct;35(4):709-15.
●Toiyama Y et,al. Soluble intercellular adhesion molecule-1 as a prognostic marker for stage II colorectal cancer patients. Ann Surg Oncol. 2008 Jun;15(6):1617-24.
●Toiyama Y et,al. Serum immunosuppressive acidic protein reflects systemic deterioration of colorectal cancer patient condition. J Surg Oncol. 2008 Apr 1;97(5):404-8.
●Toiyama Y et,al. Alteration of the chemoresistant gene expression during chemotherapy for colon cancer: a molecular case report. Oncology reports. 04/2008; 19(3):755-9.
●Toiyama Y et,al.The range of optimal concentration and mechanisms of paclitaxel in radio-enhancement in gastrointestinal cancer cell lines. Cancer Chemother Pharmacol. 2007 May;59(6):733-42
●Toiyama Y et,al.TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. World journal of gastroenterology : WJG. 06/2007; 13(19):2717-21.
●Toiyama Y et,al.Administration sequence-dependent antitumor effects of paclitaxel and 5-fluorouracil in the human gastric cancer cell line MKN45. Cancer chemotherapy and pharmacology. 03/2006; 57(3):368-75.
●Toiyama Y et,al The expression patterns of Toll-like receptors in the ileal pouch mucosa of postoperative ulcerative colitis patients. Surgery today. 02/2006; 36(3):287-90.
●Toiyama Y et,al Secondary pouchitis in a post-operative patient with ulcerative colitis, successfully treated by salvage surgery.World journal of gastroenterology : WJG. 12/2005; 11(43):6888-90.
●Toiyama Y et,al Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma. World journal of gastroenterology : WJG. 10/2005; 11(33):5151-5.
●Toiyama Y et,al Fulminant ulcerative colitis during pregnancy successfully treated by three-stage operation. Journal of gastroenterology. 02/2004; 39(3):300-1.

所属学会

●日本外科学会　　　　　　　　　　　　　　　　　　　　　　●日本消化器外科学会
●日本大腸肛門病学会　　　　　　　　　　　　　　　　　　　●日本臨床外科学会
●日本内視鏡外科学会　　　　　　　　　　　　　　　　　　　●日本癌治療学会
●日本消化器病学会　　　　　　　　　　　　　　　　　　　　●日本癌学会
●日本胃癌学会　　　　　　　　　　　　　　　　　　　　　　●日本消化管学会