2012年更新

主な保有技術

●心室再同期療法(両室ペースメーカー埋め込み)

社会活動

●2011年～　The American Society of Echocardiography: Editorial Consultant
●2010年　第12回三重超音波研究会　大会長
●2008年　第55回日本臨床検査医学会学術集会市民公開講座講演:血管が傷つくとどうなるの？-動脈硬化により生じる疾患-

受賞

●2010年度　医科学応用研究財団研究助成
●2009年度　三重県医師会医学奨励賞
●2006年　第32回　日本心臓財団研究奨励
●2004年　American Society of Echocardiography: Research Fellowship Award

英語論文

●Takeshi Takamura, Kaoru Dohi, Akitoshi Satomi, Kazuki Mori, Keishi Moriwaki, Tadafumi Sugimoto, Masahide Horiguchi, Shigetoshi Sakabe, Akihiro Kawamura, Tetsuya Seko, Atsunobu Kasai, Masaaki Ito. Intra-Aortic Balloon Pump Induced Dynamic Left Ventricular Outflow Tract Obstruction and Cardiogenic Shock after Very Late Stent Thrombosis in the Left Anterior Descending Coronary Artery. Journal of Cardiology Cases in press.
●Nakamori S, Onishi K, Nakajima H, Yoon YE, Nagata M, Kurita T, Yamada T, Kitagawa K, Dohi K, Nakamura M, Sakuma H, Ito M. Impaired Myocardial Perfusion Reserve in Patients With Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion Magnetic Resonance Imaging. Circ J. 2012 Jun 2. [Epub ahead of print]
●Watanabe K, Hoshino K, Dohi K, Saito N, Hashimoto T, Ogihara Y, Kumagai N, Nakamura M, Ito M. A Case of Dual Coronary Sinus Fistulas Originating From Right Coronary Artery and Left Ventricle. Can J Cardiol. 2012 May 1. [Epub ahead of print]
●Kakuta K, Dohi K, Yamada T, Yamanaka T, Kawamura M, Nakamori S, Nakajima H, Tanigawa T, Onishi K, Yamada N, Nakamura M, Nobori T, Ito M. Comparison of Coronary Flow Velocity Reserve Measurement by Transthoracic Doppler Echocardiography with 320-Row Multidetector Computed Tomography Coronary Angiography in the Detection of In-Stent Restenosis in the Three Major Coronary Arteries. Am J Cardiol. 2012 2012 Jul 1;110 (1):13-20.
●Masuda C, Dohi K, Sakurai Y, Bessho Y, Fukuda H, Fujii S, Sugimoto T, Tanabe M, Onishi K, Shiraki K, Ito M, Nobori T. Impact of Chronic Kidney Disease on the Presence and Severity of Aortic Stenosis in Patients at High Risk for Coronary Artery Disease. Cardiovasc Ultrasound. 2011, in press.
●Takamura T, Dohi K, Onishi K, Sakurai Y, Ichikawa K, Tsuji A, Ota S, Tanabe M, Yamada N, Nakamura M, Nobori T, Ito M. Reversible Left Ventricular Regional Non-Uniformity Quantified by Speckle-Tracking Displacement and Strain Imaging in Patients with Acute Pulmonary Embolism. J Am Soc Echocardiogr. 2011. Jul;24(7):792-802.
●Murata T, Dohi K, Onishi K, Sugiura E, Fujimoto N, Ichikawa K, Ishikawa E, Nakamura M, Nomura S, Takeuchi H, Nobori T, Ito M. Role of haemodialytic therapy on left ventricular mechanical dyssynchrony in patients with end-stage renal disease quantified by speckle-tracking strain imaging. Nephrol Dial Transplant. 2011 May;26(5):1655-61
●Nakajima H, Onishi K, Kurita T, Ishida M, Nagata M, Kitagawa K, Dohi K, Nakamura M, Sakuma H, Ito M. Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia. Hypertens Res. 2010 ;33:1144-1149.
●Takamura T, Dohi K, Onishi K, Tanabe M, Sugiura E, Nakajima H, Ichikawa K, Nakamura M, Nobori T, Ito M. Left Ventricular Contraction-Relaxation Coupling in Normal, Hypertrophic, and Failing Myocardium Quantified by Speckle-Tracking Global Strain and Strain Rate Imaging. J Am Soc Echocardiogr. 2010;23:747-754.
●Mizutani H, Okamoto R, Moriki N, Konishi K, Taniguchi M, Fujita S, Dohi K, Onishi K, Suzuki N, Satoh S, Makino N, Itoh T, Hartshorne DJ, Ito M. Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function. Circ J. 2010 Jan;74(1):120-8.
●Sugiura E, Dohi K, Onishi K, Takamura T, Tsuji A, Ota S, Yamada N, Nakamura M, Nobori T, Ito M. Reversible right ventricular regional non-uniformity quantified by speckle-tracking strain imaging in patients with acute pulmonary thromboembolism. J Am Soc Echocardiogr. 2009;22:1353-1359.
●Kurita T, Onishi K, Dohi K, Takamura T, Fujimoto N, Tanigawa T, Imanaka-Yoshida K, Wada H, Nobori T, Ito M. Conventional therapy with an ACE inhibitor diminishes left ventricular dyssynchrony during the progression of heart failure. Int J Cardiol. 2010 Apr 1;140(1):48-54.
●Fujimoto N, Onishi K, Dohi K, Tanabe M, Kurita T, Takamura T, Yamada N, Nobori T, Ito M. Hemodynamic characteristics of patients with diastolic heart failure and hypertension. Hypertens Res. 2008 Sep;31(9):1727-35.
●Takamura T, Onishi K, Sugimoto T, Kurita T, Fujimoto N, Dohi K, Tanigawa T, Isaka N, Nobori T, Ito M. Response to: Study of Left Ventricular Long Axis Function in Patients with Hypertensive Response to Exercise. Hypertens Res. 2008;31(7):1486
●Tanabe M, Dohi K, Onishi K, Nakata T, Sato Y, Nakajima H, Takamura T, Miyahara M, Nakamura M, Takeda K, Ito M. Biventricular pacing worsened dyssynchrony in heart failure patient with right-bundle branch block. Int J Cardiol. 2010 Feb 4;138(3):e47-50
●Kato S, Onishi K, Yamanaka T, Takamura T, Dohi K, Yamada N, Wada H, Nobori T, Ito M. Exaggerated hypertensive response to exercise in patients with diastolic heart failure. Hypertens Res. 2008;31:679-84.
●López-Candales A, Rajagopalan N, Dohi K, Edelman K, Gulyasy B. Normal range of mechanical variables in pulmonary hypertension: a tissue Doppler imaging study. Echocardiography. 2008 Sep;25(8):864-72.
●Dohi K, Onishi K, Gorcsan J 3rd, López-Candales A, Takamura T, Ota S, Yamada N, Ito M. Role of radial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overload. Am J Cardiol. 2008;101:1206-12.
●Takamura T, Onishi K, Sugimoto T, Kurita T, Fujimoto N, Dohi K, Tanigawa T, Isaka N, Nobori T, Ito M. Patients with a hypertensive response to exercise have impaired left ventricular diastolic function. Hypertens Res. 2008;31:257-63.
●López-Candales A, Dohi K, Rajagopalan N, Edelman K, Gulyasy B, Bazaz R. Defining normal variables of right ventricular size and function in pulmonary hypertension: an echocardiographic study. Postgrad Med J. 2008;Jan;84(987):40-5.
●Kurita T, Onishi K, Motoyasu M, Kitamura T, Takamura T, Fujimoto N, Tanabe M, Dohi K, Tanigawa T, Isaka N, Ito M, Sakuma H.　Two cases of dilated cardiomyopathy with right ventricular wall degeneration　demonstrated by late gadolinium enhanced MRI. Int J Cardiol. 2007 Aug 7.
●Lopez-Candales A, Rajagopalan N, Dohi K, Gulyasy B, Edelman K, Bazaz R. Abnormal right ventricular myocardial strain generation in mild pulmonary　hypertension. Echocardiography. 2007;24:615-622.
●Kurita T, Onishi K, Dohi K, Tanabe M, Fujimoto N, Tanigawa T, Setsuda M, Isaka N, Nobori T, Ito M. Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration. Eur J Heart Fail. 2007 Jun-Jul;9(6-7):637-43.
●Takamura T, Dohi K, Onishi K, Kurita T, Tanabe M, Tanigawa T, Isaka N, Ito M. Improvement of Left Ventricular Mechanical Dyssynchrony Associated with Restoration of Left Ventricular Function in a Patient with Fulminant Myocarditis and Complete Left Bundle Branch Block. Int J Cardiol. 2008 Jun 23;127(1):e8-11.
●Yamanaka-Funabiki K, Onishi K, Tanabe M, Dohi K, Ito M, Ohte N, Nobori T, Nakano T. Single beat determination of regional myocardial strain measurements in patients with atrial fibrillation. J Am Soc Echocardiogr. 2006;19(11):1332-7.
●Kurita T, Kitamura T, Yamanaka T, Tanabe M, Dohi K, Tanigawa T, Onishi K, Ito M, Isaka N, Nakano T. Antique SVG with two humps: A case of two giant aneurysms of single saphenous vein bypass graft. Int J Cardiol. 2007 Mar 20;116(2):e68-70.
●Yamanaka T, Onishi K, Tanabe M, Dohi K, Funabiki-Yamanaka K, Fujimoto N, Kurita T, Tanigawa T, Kitamura T, Ito M, Nobori T, Nakano T. Force- and relaxation –frequency relations in patients with diastolic heart failure. Am Heart J. 2006 152:966. e1-7.
●Rajagopalan N, Dohi K, Simon MA, Suffoletto M, Edelman K, Murali S, Lopez-Candales A. Right ventricular dyssynchrony in heart failure: a tissue Doppler imaging study. J Card Fail. 2006 May;12(4):263-7.
●Lopez-Candales A, Dohi K, Iliescu A, Peterson RC, Edelman K, Bazaz R. An abnormal right ventricular apical angle is indicative of global right ventricular impairment. Echocardiography. 2006 May;23(5):361-8.
●Dohi K, Pinsky MR, Kanzaki H, Severyn D, Gorcsan J 3rd. Effects of radial left ventricular dyssynchrony on cardiac performance using quantitative tissue Doppler radial strain imaging. J Am Soc Echocardiogr. 2006 May;19(5):475-82.
●Tanabe M, Onishi K, Dohi K, Kitamura T, Ito M, Nobori T, Nakano T. Assessment of left ventricular systolic function in patients with chronic atrial fibrillation and dilated cardiomyopathy using the ratio of preceding to prepreceding R-R intervals. Int J Cardiol. 2006 Apr 4;108(2):197-201. Epub 2005 Jun 2.
●Suffoletto MS, Dohi K, Cannesson M, Saba S, Gorcsan J 3rd. Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy. Circulation. 2006 Feb 21;113(7):960-8. Epub 2006 Feb 13.
●Dohi K, Suffoletto M, Murali S, Bazaz R, Gorcsan J. Benefit of cardiac resynchronization therapy to a patient with a narrow QRS complex and ventricular dyssynchrony identified by tissue synchronization imaging. Eur J Echocardiogr. 2005 Dec;6(6):455-60. Epub 2005 Apr 2.
●Simon MA, Kormos RL, Gorcsan J 3rd, Dohi K, Winowich S, Stanford E, Carozza L, Murali S. Differential exercise performance on ventricular assist device support. J Heart Lung Transplant. 2005 Oct;24(10):1506-12.
●Nakajima K, Onishi K, Dohi K, Tanabe M, Kurita T, Yamanaka T, Ito M, Isaka N, Nobori T, Nakano T. Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levels. Int J Cardiol. 2005 Oct 10;104(3):332-7.
●Lopez-Candales A, Dohi K, Rajagopalan N, Suffoletto M, Murali S, Gorcsan J, Edelman K. Right ventricular dyssynchrony in patients with pulmonary hypertension is associated with disease severity and functional class. Cardiovasc Ultrasound. 2005 Aug 29;3:23.
●Lopez-Candales A, Dohi K, Bazaz R, Edelman K. Relation of right ventricular free wall mechanical delay to right ventricular dysfunction as determined by tissue Doppler imaging. Am J Cardiol. 2005 Aug 15;96(4):602-6.
●Dohi K, Suffoletto MS, Schwartzman D, Ganz L, Pinsky MR, Gorcsan J 3rd. Utility of echocardiographic radial strain imaging to quantify left ventricular dyssynchrony and predict acute response to cardiac resynchronization therapy. Am J Cardiol. 2005 Jul 1;96(1):112-6.
●Dohi K, Suffoletto M, Ganz L, Zenati M, Gorcsan J 3rd. Utility of echocardiographic tissue synchronization imaging to redirect left ventricular lead placement for improved cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2005 May;28(5):461-5.
●Fujimoto N, Onishi K, Tanabe M, Dohi K, Funabiki K, Kurita T, Yamanaka T, Nakajima K, Ito M, Nobori T, Nakano T. Nitroglycerin improves left ventricular relaxation by changing systolic loading sequence in patients with excessive arterial load. J Cardiovasc Pharmacol. 2005 Mar;45(3):211-6.
●Tanabe M, Onishi K, Dohi K, Funabiki K, Koji T, Kitamura T, Ito M, Nobori T, Nakano T. Change in filling pattern with preload reduction reflects left ventricular relaxation. Int J Cardiol. 2005 Jan;98(1):67-72.
●Funabiki K, Onishi K, Dohi K, Koji T, Imanaka-Yoshida K, Ito M, Wada H, Isaka N, Nobori T, Nakano T. Combined angiotensin receptor blocker and ACE inhibitor on myocardial fibrosis and left ventricular stiffness in dogs with heart failure. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2487-92.
●Kanzaki H, Bazaz R, Schwartzman D, Dohi K, Sade LE, Gorcsan J 3rd. A mechanism for immediate reduction in mitral regurgitation after cardiac resynchronization therapy: insights from mechanical activation strain mapping. J Am Coll Cardiol. 2004 Oct 19;44(8):1619-25.
●Sade LE, Kanzaki H, Severyn D, Dohi K, Gorcsan J 3rd. Quantification of radial mechanical dyssynchrony in patients with left bundle branch block and idiopathic dilated cardiomyopathy without conduction delay by tissue displacement imaging. Am J Cardiol. 2004 Aug 15;94(4):514-8.
●Onishi K, Dohi K, Koji T, Funabiki K, Kitamura T, Imanaka-Yoshida K, Ito M, Nobori T, Nakano T. Candesartan prevents myocardial fibrosis during progression of congestive heart failure. J Cardiovasc Pharmacol. 2004 Jun;43(6):860-7.
●Gorcsan J 3rd, Kanzaki H, Bazaz R, Dohi K, Schwartzman D. Usefulness of echocardiographic tissue synchronization imaging to predict acute response to cardiac resynchronization therapy. Am J Cardiol. 2004 May 1;93(9):1178-81.
●Tanabe M, Onishi K, Dohi K, Ito M, Nakano T, Suga H. Alternans decay of postextrasystolic potentiation in human left ventricle. Jpn J Physiol. 2004 Feb;54(1):87-91.
●Sade LE, Severyn DA, Kanzaki H, Dohi K, Gorcsan J 3rd. Second-generation tissue Doppler with angle-corrected color-coded wall displacement for quantitative assessment of regional left ventricular function. Am J Cardiol. 2003 Sep 1;92(5):554-60.
●Koji T, Onishi K, Dohi K, Okamoto R, Tanabe M, Kitamura T, Ito M, Isaka N, Nobori T, Nakano T. Addition of angiotensin II receptor antagonist to an ACE inhibitor in heart failure improves cardiovascular function by a bradykinin-mediated mechanism. J Cardiovasc Pharmacol. 2003 Apr;41(4):632-9.
●Kitamura T, Onishi K, Dohi K, Okinaka T, Ito M, Isaka N, Nakano T. Circadian rhythm of blood pressure is transformed from a dipper to a non-dipper pattern in shift workers with hypertension. J Hum Hypertens. 2002 Mar;16(3):193-7.
●Mizuno O, Onishi K, Dohi K, Motoyasu M, Okinaka T, Ito M, Isaka N, Nakano T. Effects of therapeutic doses of human atrial natriuretic peptide on load and myocardial performance in patients with congestive heart failure. Am J Cardiol. 2001 Oct 15;88(8):863-6.
●Dohi K, Onishi K, Kitamura T, Okinaka T, Ito M, Isaka N, Nakano T. Functional role of endogenous endothelin-1 in congestive heart failure treated with angiotensin II receptor antagonist. Jpn J Physiol. 2001 Aug;51(4):445-53.
●Kitamura T, Onishi K, Dohi K, Okinaka T, Isaka N, Nakano T. The negative inotropic effect of beta3-adrenoceptor stimulation in the beating guinea pig heart. J Cardiovasc Pharmacol. 2000 May;35(5):786-90.

日本語論文

●渡辺清孝、土肥薫、中嶋寛、佐藤雄一、杉浦英美喜、杉本匡史、中森史朗、藤井英太郎、山田典一、中村真潮、伊藤正明　心臓再同期療法とオクトレオチド療法の併用により劇的な左室逆リモデリングが認められた先端巨大症合併心不全の1例　日本心臓病学会誌　J Cardiol Jpn Ed 2012 in-press.
●土肥薫、伊藤正明、トルバプタン長期投与によりフロセミド減量と適切な体液管理に成功した慢性心不全の一症例 医薬ジャーナル　2012年2月号　(Vol.48 No.2) P145(723)～150(728).
●田之上明子、石川英二、平本拓也、松尾浩司、藤本美香、村田智博、土肥薫、野村信介、伊藤正明　重症心不全に腹膜透析を導入し体液管理が可能となったが、残存腎機能低下により体液コントロールに難渋した一症例　腎と透析　2011年71巻　322-323
●大西勝也、土肥薫、熊谷直人、中嶋寛、中森史朗、星野康三、中村真潮、大西正文、伊藤正明　高血圧患者に対するvalsartanとamlodipine配合錠の効果および安全性の評価　新薬と臨牀 60(8):1560-1567 2011
●大西勝也、土肥薫、北村哲也、中村真潮、大西正文、伊藤正明　慢性心不全を合併する2型糖尿病患者に対するDPP-4阻害薬シタグリプチンの効果および安全性の評価　Therapeutic Research（2011年32巻6号835頁～840頁）
●近藤真理、中嶋寛、土肥薫、伊藤貴康、松尾浩司、杉本匡史、坂井正孝、田辺正樹、玉田浩也、山田典一、宮原眞敏、中村真潮、伊藤正明　恒久的右室ペーシング治療により難治性右心不全から脱却できた徐脈性心房細動の1例　日本心臓病学会誌　J Cardiol Jpn Ed Vol.6　No.1　81-86.　February 2011
●高村武志、土肥薫、藤田聡、中嶋寛、田辺正樹、玉田浩也、大西勝也、宮原眞敏、中村真潮、伊藤正明　収縮性心外膜炎様の血行動態を呈し、胸水穿刺により劇的な改善を認めた難治性心不全の1例　呼吸と循環2010;58:639-644.
●北村哲也、岩﨑仁史、土肥薫、谷川高士、藤井英太郎、大西勝也、山田典一、中井久太夫、中村真潮、井阪直樹、伊藤正明　高脂血症治療中、CPK・AST・ALT上昇を認める患者におけるpitavastatinの有効性・安全性に関する検討　循環器科2009;65:440-4.
●大西勝也、土肥薫　Valsartan 80mgとHydrochlorothiazide 12.5mgの併用療法における有効性と安全性の検討　Olmesartan 20mgで降圧が不十分な患者から変更後の血圧推移　診療と新薬2009;46:250-5.
●藤本直紀、藤井英太郎、千賀通晴、栗田泰郎、土肥薫、山田典一、井阪直樹、伊藤正明　アミオダロン内服中に好酸球増多を認めた2症例　Prog Med 2008;28 Suppl1:644-8.
●佐藤雄一、土肥薫、千賀通晴、藤本直紀、玉田浩也、藤井英太郎、大西勝也、山田典一、宮原眞敏、中村真潮、井阪直樹、伊藤正明　房室結節焼灼術と心臓再同期療法により救命できた心原性ショックの1例　心臓2008;40:976-80.
●千賀通晴、土肥薫、熊谷直人、高村武志、藤本直紀、栗田泰郎、藤井英太郎、太田覚史、谷川高士、北村哲也、大西勝也、山田典一、中村真潮、大久保節也、井阪直樹、伊藤正明　薬剤抵抗性の重症右心不全に対して右室ペーシングが著効した1例 Therapeutic Research 2007；28:586-9.
●藤井英太郎、藤本直紀、栗田泰郎、山中崇、岡本隆二、土肥薫、谷川高士、北村哲也、大西勝也、伊藤正明、井阪直樹、中野赴　Bachmann束ペーシング単独での心房細動予防効果の検討　セラピューティック・リサーチ2006;27:1802-5.
●大西勝也、土肥薫、田辺正樹、幸治隆文、伊藤正明、中野赳 心不全患者におけるヒト心房性ナトリウム利尿ペプチド(hANP)の心収縮能,拡張能に及ぼす影響 心臓2003;35: 58-61.
●土肥薫、大西勝也、中野赳　カルシウム感受性増強剤、MCI-154の心機能に及ぼす影響　日本臨床生理学会雑誌 2001;31:117-121.
●土肥薫、大西勝也、北村哲也、石須良一、井阪直樹、中野赳　カルシウム感受性と心機能　日本臨床生理学会雑誌　2000;30:54.
●土肥薫、江見吉晴、森拓也、中井久太夫、中野赳 感染性心内膜炎に合併した大腿動脈の細菌性動脈瘤の1例　脈管学1997;9:485-8.

著書

●土肥薫　拡張期心不全を心エコーで診る　心エコー(責任編集者:吉川純一)2011年12月号(12巻12号) P1148～1155 2011年 文光堂
●土肥薫 Yu-indexはdyssynchrony評価に有用である 心エコー(責任編集者:吉川純一)2009年11月号 (10巻11号) P994～1001 2009年 文光堂
●土肥薫 心エコー・ドプラ法による収縮期心不全の診かた 心エコー(責任編集者:吉川純一)2009年3月号 (10巻3号) P262～269 2009年 文光堂
●土肥薫、伊藤正明 エビデンスに基づく食事・運動・薬物療法の進め方:合併症を考慮した運動療法 高血圧診療ハンドブック(編集:浦信行)2009年 羊土社
●大西勝也、土肥薫、中野赳 カルシウム制御薬と拡張不全 CLINICAL CALCIUM 2000年11月号(Vol.10 No.11) P55(1419)～59(1423) 2000年 医薬ジャーナル社

応用分野

●医療分野

主な保有機器・装置

●心臓超音波検査機器(GE横河メディカル株式会社:VIVID7、東芝メディカルシステムズ株式会社:ARTIDA)
●心機能測定装置(日本光電工業株式会社:TFM-3040 タスクフォースモニタ)

関連ホームページ

• 三重大学大学院循環器腎臓内科学講座　心不全・心機能研究グループ