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2012年更新
カテゴリ
医学・薬学
キーワード
頭頸部癌 嚥下 上気道 mucin

一言アピール

臨床は地域医療格差をなくすことをとりあえずの目標にしています、研究は臨床に応用できる新しい何かを発見したいです。


研究テーマ

  1. ●気道上皮における粘液産生の機序や防御機構の解明について
  2. ●頭頸部癌の早期発見や予防について

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論文

●The role of transforming growth factor-α on mucin overproduction in eosinophilic chronic rhinosinusitis.Pharmacology. 2011;88(5-6):302-8. 2011
●Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea.Pharmacology. 2011;87(1-2):56-62. 2011
●Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line.Pharmacology. 2011;88(5-6):327-32. 2011
●Remodeling of nasal mucosa by allergen exposure in guinea pigs is suppressed by steroid and pranlukast.Rhinology. 2009 Jun;47(2):199-206. 2009
●Remodeling of nasal mucosa by allergen exposure in guinea pigs is suppressed by steroid and pranlukast.Rhinology. 2009 Jun;47(2):199-206. 2009
●Synergistic induction of nuclear factor-kappaB by transforming growth factor-beta and tumour necrosis factor-alpha is mediated by protein kinase A-dependent RelA acetylation. Biochem J. 2009 Jan 15;417(2):583-91. 2009
●Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling.J Biol Chem. 2008 May 2;283(18):12546-54. 2008
●Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells.Pharmacology. 2008;81(3):221-8. 2008
●Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice.PLoS One. 2007 Oct 10;2(10):e1032. 2007
●Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity. 2007 Aug;27(2):349-60. 2007
●TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J. 2007 Feb 21;26(4):1150-62. 2007
●Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK.Biochem Biophys Res Commun. 2006 Dec 15;351(2):368-75. 2006
●The transforming growth factor-beta-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation with NF-kappaB and MAPK phosphatase 1-dependent negative cross-talk with p38 MAPK.J Biol Chem. 2006 Aug 4;281(31):22397-408. 2006
●Malignant external otitis: treatment with prolonged usage of antibiotics and Burow's solution. Auris Nasus Larynx. 2005 Dec;32(4):403-6. 2006
●Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. Pharmacology, 73(2): 89-96. 2005
●Roxithromycin suppresses mucin gene expression in epithelial cells. Pharmacology. 2004 Sep;72(1):6-11. 2004
●High-pressure grease injury of the face. Am J Otolaryngol. 2004 Jul-Aug;25(4):278-81. 2004
●Long-term outcome of benign paroxysmal positional vertigo. Neurology. 2003 May 13;60(9):1532-4. 2003
●A case of bilateral cervical lymph node metastasis of thyroglossal duct cancer.
Auris Nasus Larynx. 2003 Feb;30(1):107-11. 2003
●Mucin gene expression in the effusions of otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2003 Jan;67(1):53-8. 2003
●Pendred’s syndrome with goiter and enlarged vestibular aqueducts diagnosed by PDS gene mutation. Head Neck, 24(7): 710-713. 2002
●Effects of dexamethasone on mucin gene expression in cultured human nasal epithelial cells. Laryngoscope, 112: 1436-1440. 2002
●Histamine alters gene expression in cultured human nasal epithelial cells. J Allergy Clin Immunol. 2001 Feb;107(2):310-4. 2001

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