• トップ
  • 【連携事例】未利用資源・加工副産物に含まれる機能性成分の探索【イラストマンガで紹介!】

お問い合わせ

医療・福祉

環境

バイオ

農林・水産

医薬品

食料

評価・分析

【連携事例】未利用資源・加工副産物に含まれる機能性成分の探索【イラストマンガで紹介!】

想定される用途

・食品等から出る未利用資源や加工副産物の活用

想定される連携形態

・食品メーカ等において利活用を検討している未利用資源や加工副産物の機能性の探索に関する共同研究

【連携事例】未利用資源・加工副産物に含まれる機能性成分の探索【イラストマンガで紹介!】

所属・役職

生物資源学研究科・准教授

研究者氏名

伊藤 智広

概要

目的とした食品を加工する過程では、その製造過程で多くの副産物が発生します。それらには、多くの機能成分が含まれており、私達は天然物に含まれる機能性成分を100%活用できていません。現場では、これらを廃棄物としてコストをかけて処理していますが、これら副産物に含まれる機能性成分の特徴を知ることで、新たな商品の開発と廃棄物コストの低減に繋がります。つまり、新たな機能性商品によるヒト(消費者)の健康維持と地球環境の負荷軽減に貢献することになります。
これまでに、和菓子原料の一つである小豆の餡製造過程における小豆煮汁から抗腫瘍、血糖値上昇抑制、血清コレステロールの低減、メラニン生成調節機構などを、カマボコ製造時に発生する魚骨残渣から高血圧改善効果など見出し、商品への開発に結びつけています。

アピールポイント

ここでは一例としてアズキの煮汁の研究成果をご紹介していますが、研究対象とする素材は加工副産物だけではなく、利用度の低いマイナーな食材など幅広く取扱っております。また、実験についても細胞レベルの実験から動物実験まで対応しています。もし貴社にて研究対象としてお考えの素材がありましたらご相談ください。

補足資料(動画)

補足資料(マンガ)

↓↓上記研究内容をわかりやすくイラストマンガで紹介しております。是非ご覧ください!
(下記画像をクリックするとマンガ(ファイルサイズ:2.3MB)が表示されます。)

補足資料(スライド)

特許情報

(1)発明の名称:アポトーシス誘導性癌細胞増殖抑制剤、公開番号:特開2001-151687 PDF
(2)発明の名称:抗腫瘍物質、公開番号:特開2003-63967 PDF
(3)発明の名称:アレルギー疾患用治療剤または予防剤、公開番号:特開2010-275241 PDF
(4)発明の名称:抗アレルギー剤、公開番号:特開2010-202598 PDF
(5)発明の名称:間葉系細胞分化を調節するための薬剤及びその利用、公開番号:特開2013-91611 PDF
(6)発明の名称:アズキ由来抗アレルギー剤 及びこれを含有する食品、公開番号:特開2011-178680 PDF
(7)発明の名称:一酸化窒素産生抑制剤および抗炎症剤、登録番号:特許第6037548号 PDF
(8)発明の名称:オートファジー性細胞死誘導剤、登録番号:特許第5767687号 PDF
(9)発明の名称:抗アクネ菌剤、登録番号:特許第5846069号 PDF
(10)発明の名称:アズキ由来骨代謝調節剤、公開番号:特開2014-091686 PDF

論文情報

【2017年】
・Tomohiro Itoh Yasuyoshi Miyake, Takayuki Yamaguci, Shota Tsukaguchi, Rena Mitarai, Miyuki Enomoto, Seiya Ensho, Yoshie Shimomiya, Yuki Nakamura, Masashi Ando, Yasuyuki Tsukamasa, Muneaki Takahata. OM-X®, fermented vegetables extract facilitates muscle endurance capacity in swimming exercise mice. Natural Products Communications, 12, 111-114.
【2016年】
・Tomohiro Itoh, Azusa Fujiwara, Masayuki Ninomiya, Toshimichi Maeda, Masashi Ando, Yasuyuki Tsukamasa, Mamoru Koketsu.
Inhibitory effects of echinochrome A, isolated from shell of sea urchin Anthocidaris crassispina on antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells through the suppressing of Lyn activation.
Natural Products Communications, 10, 1303-1306.
【2015年】
・Tomohiro Itoh, Yasuyoshi Miyake, Takuya kasashima, Yoshie Shimomiya, Yuki Nakamura, Masashi Ando, Yasuyuki Tsukamasa, Muneaki Takahata.
OM-X®, fermented vegetables extract suppresses antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
Natural Products Communications, 10, 1597-1601.
​【2014年】
・Tomohiro Itoh, Masahiro Nakamura, Hirohisa Nakamichi, Masashi Ando, Yasuyuki Tsukamasa, Yukio Furuichi.
Regulation of the differentiation of osteoblasts and osteoclasts by a hot-water extracts of adzuki beans (Vigna angularis).
Bioscience, Biotechnology, and Biochemistry, 78, 92-99.
・Wen Jye Mok, Yoshirou Hatanaka, Manabu Seoka, Tomohiro Itoh, Yasuyuki Tsukamasa, Masashi Ando.
Effects of additional cysteine in fish diet on mercury concentration.
Food Chemistry 147, 340-345.
・Masashi Ando, Takamitsu Fukai, Ken-ichi Kawasaki, Tomohiro Itoh, and Yasuyuki Tsukamasa.
Improvement of Red Color Development on the Surface of Kuruma Prawn Marsupenaeus japonicus under Various Conditions.
Journal of Food Science, 79, E202-207.
​【2013年】
・Tomohiro Itoh, Ryosuke Tsuzuki, Toshiomi Tanaka, Masayuki Ninomiya, Yuji Yamaguchi, Hiroyuki Takenaka, Masashi Ando, Yasuyuki Tsukamasa, Mamoru Koketsu.
Reduced scytonemin isolated from Nostoc commune induces autophagic cell death in Human T-lymphoid cell line Jurkat cells.
Food and Chemical Toxicology 60, 76-82.
・伊藤智広、阪田雄大、吉田ゆに華、岩山昌弘、村瀬博宣、安藤正史、塚正泰之
ラット好塩基球細胞株RBL-2H3 細胞における抗原刺激後脱顆粒に及ぼすタツノオトシゴ(Hippocampus kelloggi Jordan)エタノール抽出物の抑制効果
日本水産学会誌 79, 683-693.
・Akio Iio, Mikako Ito, Tomohiro Itoh, Riyako Terazawa, Yasunori Fujita Yoshinori Nozawa, Ikuroh Ohsawa, Kinji Ohno, Masafumi Ito.
Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through inhibiting JNK activation and CD36 expression in HepG2 cells
Medical Gas Research 3:6 doi:10.1186/2045-9912-3-6 .
・Riyako Terazawa, Nozomi Akimoto, Tomohiro Itoh, Yasunori Fujita, Nanako Hamada, Takashi Deguchi, Munekazu Iinuma, Mami Noda, Yoshinori Nozawa, Masafumi Ito.
A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells.
Pharmacology Research 60, 76-82.
・Yasuyuki Tsukamasa, Keisuke Kato, Bimol Chandra Roy, Yasunori Ishibashi,Toru Kobayashi, Tomohiro Itoh, Masashi Ando.
Novel method for improving the antioxidative properties of fish meat by direct injection of sodium L-ascorbate into the blood vessels of live fish.
Fisheries Science 79, 349-355.
​【2012年】
・Tomohiro Itoh, Masashi Ando, Yasuyuki Tsukamasa, Yukihiro Akao.
Expressions of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation areis regulated by microRNA-370.
FEBS Letters 586,1693-1701.
・Tomohiro Itoh, Yumiko Hori, Atsumi, Kazuo Toriizuka, Masahiro Nakamura, Takeshi Maeyama, Masashi Ando, Yasuyuki Tsukamasa, Yoshimitsu Ida, Yukio Fruichi.
Inhibitory effects of hot water extract of adzuki on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
Phytotherapy Research 26, 1003-1011.
・Tomohiro Itoh, Yasuyoshi Miyake, Ayumi Onda, Junko Kubo, Masashi Ando, Yasuyuki Tsukamasa, Muneaki Takahata.
Immunomodulatory effects of heat-killed Enterococcus faecalis TH10 on murine macrophage cells.
MicrobiologyOpen 1, 373–380.
・Tomohiro Itoh, Masashi Ando, Yasuyuki Tsukamasa.
Whisky congeners suppress LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by the inducing hemeoxygenase-1 expression.
Journal of Agricultural Food Chemistry 60, 12491-12500.
・Tomohiro Itoh, Yuko Ito, Yoshinori Ohtsuki, Masashi Ando, Yasuyuki Tsukamasa, Nami Yamada,Tomoki Naoe, Yukihiro Akao.
Microvesicles released from hormone-refractory prostate cancer cells facilitate mouse pre-osteoblast differentiation.
Journal of Molecular Histology 43,509-515.
・Roy Bimol Chandra, Ando Masashi, Tsukamasa Yasuyuki, Itoh Tomohiro.
Structural and ultrastructural changes of full-cycle cultured Pacific bluefin tuna (Thunnus orientalis) muscle slices during chilled storage.
Journal of The Science of Food and Agriculture 92, 1755-1764.
・Morina Adafa, Tomohiro Itoh, Mamoru Koketsu.
Inhibitory Effects of 6-Alkoxycoumarin and 7-Alkoxycoumarin Derivatives on LPS/IFNγ-Stimulated Nitric Oxide Production in RAW264 Cells.
Biological & Pharmaceutical Bulletin 35, 963-966.
・Yasufumi Fukuma, Akihiko Yamane, Tomohiro Itoh, Yasuyuki Tsukamasa, Masashi Ando.
Application of supercooling to long-term storage of fish meat.
Fisheris Science 78, 451-461.
・Roy Bimol Chandra, Masashi Ando, Masahiro Nakatani, Tokihiko Okada, Yoshifumi Sawada, Tomohiro Itoh, Yasuyuki Tsukamasa.
Muscle fiber types, growth and development in the whole myotome of cultured Pacific bluefin tuna Thunnus orientalis.
Fisheris Science 78, 471-48.
・Wen Jye Mok, Shigeharu Senoo, Tomohiro Itoh, Yasuyuki Tsukamasa, Ken-ichi Kawasaki, Masashi Ando.
Assessment of concentrations of toxic elements in aquaculture food products in Malaysia.
Food Chemistry 133,1326-1332.
【2011年】
・Tomohiro Itoh, Chizuru Nakajima, Masayoshi Ohyama, Munekazu Iinuma, Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa, Masafumi Ito.
Inhibitory effects of flavonoid glycosides isolated from the peel of japanese persimmon (Fuyu-kaki) on antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.
Food Chemistry 126, 289-294.
・Tomohiro Itof, Riyako Terazawa, Keitaro Kojima, Keita Nakane, Takashi Deguchi, Masashi Ando, Yasuyuki Tsukamasa, Masafumi Ito, Yoshinori Nozawa.
Cisplatin-induced reactive oxygen species production NADPH oxidase in human prostate cancer cell lines.
Free Radical Research 45, 1033-1039.
・Tomohiro Itoh, Nanako Hamada, Riyako Terzawa, Mikako Ito, Kinji Ohno, Masatoshi Ichihara, Yoshinori Nozawa, Masafumi Ito.
Molecular hydrogen inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production through modulation of signal transduction in macrophages.
Biochemical and Biophysical Research Communications 411, 143-149.
・Yukihiro Akao, Akio Iio, Tomohiro Itoh, Shunsuke Noguchi, Yuko Itoh, Yoshinori Ohtsuki, Tomoki Naoe.
Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages.
Molecular Therapy 19, 395-399.
・Nanako Hamada, Arisa Tanaka, Yasunori Fujita, Tomohiro Itoh, Yoshiko Ono, Yoshinori Kitagawa, Namino Tomimori, Yoshinobu Kiso,Yukihiro Akao, Yoshinori Nozawa, Masafumi Ito.
Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.
Bioorganic & Medicinal Chemistry 19, 1959-1965.
【2010年】
・Tomohiro Itoh, Takeda Shu, Yukihiro Akao.
MicroRNA-208 modulates BMP-2-stimulated mouse pre-osteoblast differentiation by direct targeting V-ets erythroblastosis virus E26 oncogene homolog 1.
The Journal of Biological Chemistry 285, 27745-27752.
・Tomohiro Itoh, Masayuki Ninomiya, Yoshinori Nozawa, Yukihiro Akao, Mamoru Koketsu.
Chalcone glycosides isolated from aerial parts of Brassica rapa L. ‘hidabeni’ suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells.
Bioorganic &Medicinal Chemistry 18, 7052-7057.
・Tomohiro Itoh, Mariko Tsukane, Minako Koike, Chizu, Nakamura, Kenji Ohguchi, Masafumi Ito, Yukihiro Akao, Yoshinori Nozawa, Toshiyuki Wakimoto, Haruo Nukaya, Yoshihide Suwa. Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.
Journal of Agricultural Food Chemistry, 58, 7149-7157.
・Masayuki Ninomiya, Tomohiro Itoh, Suguru Ishikawa, Miho Saiki, Kenji Narumiya, Yoshinori Nozawa, Mamoru Koketsu.
Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation.
Bioorganic &Medicinal Chemistry 18, 5932-5937.
・Kenji Ohguchi, Chizuru Nakajima, Masayoshi Ohyama, Munekazu Iinuma, Tomohiro Itoh, Yukihiro Akao, Yoshinori Nozawa, Masafumi Ito.
Inhibitory effect of flavonoid glycosides isolated from the peel of japanese persimmon (Fuyu-kaki) on melanin biosynthesis.
Biological & Pharmaceutical Bulletin 33, 122-124.
・Yukihiro Akao, Yshihito Nakagawa, Hirata I., Akio Iio, Tomohiro Itoh, Keitaro Kojima, Remi Nakajima., Yukoi Kitade Y, Tomoyuki Naoe.
Role of microRNA-143 and -145 in human colorectal tumors.
Cancer Gene Therapy 17, 398-408.
・Kenji Ohguchi, Tomohiro Itoh, Yukihiro Akao, Hiroyasu Inoue,Yoshinori Nozawa, Masafumi Ito.
SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts.
British Journal of Dermatology 163, 689-694.
・Riyako Terazawa, Dinesh R. Garud, Nanako Hamada, Yasunori Fujita, Tomohiro Itoh,Yoshinori Nozawa, Keita Nakane, Takashi Deguchi, Mamoru Koketsu,Masafumi Ito.
Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells.
Bioorganic &Medicinal Chemistry 18, 7001-7008.
・Arisa Tanaka, Yasunori Fujita, Nanako Hamada, Tomohiro Itoh, Yoshinori Nozawa, Masaumi Ito.
A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation.
Bioorganic & Medicinal Chemistry 18, 3133-3139.